Pathophysiology of neurally mediated syncope: Role of cardiac output and total peripheral resistance

The elusive pathophysiology of neurally mediated syncope.

Syncope is defined as a sudden transient loss of consciousness and postural tone due to cerebral hypoperfusion. Although no permanent medical sequelae should result from syncope itself, isolated or recurrent events are often dramatic and disrupt the lifestyle of affected individuals. Syncope is a common clinical problem that affects up to 3.5% of the general population.1 Strikingly, in close to...

Role of Pacing in Neurally Mediated Syncope

Pharmacotherapy of neurally mediated syncope.

A wide variety of pharmacological agents are currently used for prevention of recurrent neurally mediated syncope, especially the vasovagal faint. None, however, have unequivocally proven long-term effectiveness based on adequate randomized clinical trials. At the present time, beta-adrenergic receptor blockade, along with agents that increase central volume (eg, fludrocortisone, electrolyte-co...

Neurally mediated syncope.

Neurally mediated syncope is a disorder of the autonomic regulation of postural tone, which results in hypotension, bradycardia, and loss of consciousness. A wide variety of stimuli can trigger this reflex, the most common stimulus being orthostatic stress. Typically, a patient with neurally mediated syncope experiences nausea, lightheadedness, a feeling of warmth, and pallor before abruptly lo...

Cardiac output and total peripheral resistance in carotid sinus reflex.

SCHMIDT,ROBERT M., MAMORU KUMADA, AND KIICHI SAGAWA. Cardiac output and total peripheral resistance in carotid sinus reflex. Am. J. Physiol. 221(Z) : 480-487. 197 1 .-The sensitivity of the carotid sinus baroreceptor reflex to step change in sinus pressure was studied in anesthetized dogs, with emphasis on the relative contributions of cardiac output (CO) and total peripheral resistance (TPR) i...